Mecklin JP | Seppälä Labhttps://www.seppalalab.org/author/mecklin-jp/Mecklin JPHugo Blox Builder (https://hugoblox.com)enThu, 01 Jan 2026 00:00:00 +0000https://www.seppalalab.org/media/logo_hu_e3f0d28ad302f75b.pngMecklin JPhttps://www.seppalalab.org/author/mecklin-jp/Distance-based evaluation of tumor budding in colorectal cancerhttps://www.seppalalab.org/publication/aijala-2026-distance-based/Thu, 01 Jan 2026 00:00:00 +0000https://www.seppalalab.org/publication/aijala-2026-distance-based/Impact of stromal maturity and proportion on prognosis and immune landscape in colorectal cancerhttps://www.seppalalab.org/publication/tapiainen-2026-impact/Thu, 01 Jan 2026 00:00:00 +0000https://www.seppalalab.org/publication/tapiainen-2026-impact/Integrative omics approaches to uncover liquid-based cancer-predicting biomarkers in Lynch syndromehttps://www.seppalalab.org/publication/karkkainen-2026-integrative/Thu, 01 Jan 2026 00:00:00 +0000https://www.seppalalab.org/publication/karkkainen-2026-integrative/MLH1 Lynch Syndrome Colorectal Cancers Are Driven by Heterogeneous Wnt Pathway Gene Mutationshttps://www.seppalalab.org/publication/hokkanen-2026-mlh1/Thu, 01 Jan 2026 00:00:00 +0000https://www.seppalalab.org/publication/hokkanen-2026-mlh1/Nanopore sequencing reveals hidden landscape of short L1 transductions in colorectal cancerhttps://www.seppalalab.org/publication/nummi-2026-nanopore/Thu, 01 Jan 2026 00:00:00 +0000https://www.seppalalab.org/publication/nummi-2026-nanopore/NOUS-209 Off-the-shelf Immunotherapy Has the Potential to Hit Primary and Metachronous Colorectal and Urothelial Cancers in Lynch Syndromehttps://www.seppalalab.org/publication/de-2026-nous-209/Thu, 01 Jan 2026 00:00:00 +0000https://www.seppalalab.org/publication/de-2026-nous-209/Quantitative analysis of myeloid cell patterns and immunosuppressive enzyme (IDO, ARG1) expression in colorectal cancer pulmonary metastases and corresponding primary tumourshttps://www.seppalalab.org/publication/karjula-2026-quantitative/Thu, 01 Jan 2026 00:00:00 +0000https://www.seppalalab.org/publication/karjula-2026-quantitative/Sex-based differences in circulating microRNA and metabolite signatures associated with physical activity in Lynch Syndrome carriershttps://www.seppalalab.org/publication/karkkainen-2026-sex-based/Thu, 01 Jan 2026 00:00:00 +0000https://www.seppalalab.org/publication/karkkainen-2026-sex-based/Significance of tumor infiltrating granulocytes and neutrophil extracellular traps in colorectal cancerhttps://www.seppalalab.org/publication/rahkola-2026-significance/Thu, 01 Jan 2026 00:00:00 +0000https://www.seppalalab.org/publication/rahkola-2026-significance/Tumour immune contexture and immune evasion in sporadic and Lynch syndrome-associated microsatellite unstable colorectal cancershttps://www.seppalalab.org/publication/martin-2026-tumour/Thu, 01 Jan 2026 00:00:00 +0000https://www.seppalalab.org/publication/martin-2026-tumour/Unraveling the Effects and Characteristics of Proliferating Tumor and Cytotoxic T Cells in Colorectal Cancerhttps://www.seppalalab.org/publication/kastinen-2026-unraveling/Thu, 01 Jan 2026 00:00:00 +0000https://www.seppalalab.org/publication/kastinen-2026-unraveling/Urothelium marker UPK2 identifies aggressive colorectal cancers with distinct molecular and histological featureshttps://www.seppalalab.org/publication/aijala-2026-urothelium/Thu, 01 Jan 2026 00:00:00 +0000https://www.seppalalab.org/publication/aijala-2026-urothelium/Associations of mucinous differentiation and mucin expression with immune cell infiltration and prognosis in colorectal adenocarcinomahttps://www.seppalalab.org/publication/elomaa-2025-associations/Wed, 01 Jan 2025 00:00:00 +0000https://www.seppalalab.org/publication/elomaa-2025-associations/CDX2 and SATB2 loss are associated with myeloid cell infiltration and poor survival in colorectal cancerhttps://www.seppalalab.org/publication/sirnio-2025-cdx2/Wed, 01 Jan 2025 00:00:00 +0000https://www.seppalalab.org/publication/sirnio-2025-cdx2/Characteristics and significance of gammadelta T cells in colorectal cancerhttps://www.seppalalab.org/publication/karjalainen-2025-characteristics/Wed, 01 Jan 2025 00:00:00 +0000https://www.seppalalab.org/publication/karjalainen-2025-characteristics/Colorectal cancer heterogeneity co-evolves with tumor architecture to determine disease outcomehttps://www.seppalalab.org/publication/bertillot-2025-colorectal/Wed, 01 Jan 2025 00:00:00 +0000https://www.seppalalab.org/publication/bertillot-2025-colorectal/Comprehensive characterization of micropapillary colorectal adenocarcinomahttps://www.seppalalab.org/publication/aijala-2025-comprehensive/Wed, 01 Jan 2025 00:00:00 +0000https://www.seppalalab.org/publication/aijala-2025-comprehensive/Comprehensive metabolomic and epigenomic characterization of microsatellite stable BRAF-mutated colorectal cancerhttps://www.seppalalab.org/publication/taira-2025-comprehensive/Wed, 01 Jan 2025 00:00:00 +0000https://www.seppalalab.org/publication/taira-2025-comprehensive/Constrained hypermutation and absence of TERT promoter mutations in Lynch syndrome-associated urothelial cancerhttps://www.seppalalab.org/publication/nikkola-2025-constrained/Wed, 01 Jan 2025 00:00:00 +0000https://www.seppalalab.org/publication/nikkola-2025-constrained/Genome-wide DNA methylation profiles of colorectal tumors in Lynch syndrome and familial adenomatous polyposishttps://www.seppalalab.org/publication/maki-nevala-2025-genome-wide/Wed, 01 Jan 2025 00:00:00 +0000https://www.seppalalab.org/publication/maki-nevala-2025-genome-wide/Integrating Tumor Intraepithelial CD8(+) and Stromal FOXP3(+) T-Cell Densities as an Enhanced Immune Prognostic Index in Colorectal Cancerhttps://www.seppalalab.org/publication/tuomisto-2025-integrating/Wed, 01 Jan 2025 00:00:00 +0000https://www.seppalalab.org/publication/tuomisto-2025-integrating/Multimarker Assessment of B-Cell and Plasma Cell Subsets and Their Prognostic Role in the Colorectal Cancer Microenvironmenthttps://www.seppalalab.org/publication/sirkia-2025-multimarker/Wed, 01 Jan 2025 00:00:00 +0000https://www.seppalalab.org/publication/sirkia-2025-multimarker/Performance Comparison of Droplet Digital PCR and Next-Generation Sequencing for Circulating Tumor DNA Detection in Non-Metastatic Rectal Cancerhttps://www.seppalalab.org/publication/szeto-2025-performance/Wed, 01 Jan 2025 00:00:00 +0000https://www.seppalalab.org/publication/szeto-2025-performance/Prognostic Features and Potential for Immune Therapy in Metastatic Mismatch Repair-Deficient Colorectal Cancer: A Retrospective Analysis of a Large Consecutive Population-Based Patient Serieshttps://www.seppalalab.org/publication/wirta-2025-prognostic/Wed, 01 Jan 2025 00:00:00 +0000https://www.seppalalab.org/publication/wirta-2025-prognostic/PTEN status, tumor immune microenvironment, and survival in colorectal cancerhttps://www.seppalalab.org/publication/karjalainen-2025-pten/Wed, 01 Jan 2025 00:00:00 +0000https://www.seppalalab.org/publication/karjalainen-2025-pten/Significance of mucin-suspended tumor bud-like structures in colorectal cancerhttps://www.seppalalab.org/publication/aijala-2025-significance/Wed, 01 Jan 2025 00:00:00 +0000https://www.seppalalab.org/publication/aijala-2025-significance/Significance of Th1 and Th2 Cell Densities and Th1/Th2 Cytokine Profiles in Colorectal Cancerhttps://www.seppalalab.org/publication/ojanpera-2025-significance/Wed, 01 Jan 2025 00:00:00 +0000https://www.seppalalab.org/publication/ojanpera-2025-significance/Skin cancer risk in hereditary mixed cancer syndromeshttps://www.seppalalab.org/publication/nikkola-2025-skin/Wed, 01 Jan 2025 00:00:00 +0000https://www.seppalalab.org/publication/nikkola-2025-skin/Stroma AReactive Invasion Front Areas (SARIFA), tumour immune microenvironment, and survival in colorectal cancerhttps://www.seppalalab.org/publication/tapiainen-2025-stroma/Wed, 01 Jan 2025 00:00:00 +0000https://www.seppalalab.org/publication/tapiainen-2025-stroma/Structural features of somatic and germline retrotransposition events in humanshttps://www.seppalalab.org/publication/nummi-2025-structural/Wed, 01 Jan 2025 00:00:00 +0000https://www.seppalalab.org/publication/nummi-2025-structural/Circulating metabolome landscape in Lynch syndromehttps://www.seppalalab.org/publication/jokela-2024-circulating/Mon, 01 Jan 2024 00:00:00 +0000https://www.seppalalab.org/publication/jokela-2024-circulating/Circulating miRNA Signature Predicts Cancer Incidence in Lynch Syndrome-A Pilot Studyhttps://www.seppalalab.org/publication/sievanen-2024-circulating/Mon, 01 Jan 2024 00:00:00 +0000https://www.seppalalab.org/publication/sievanen-2024-circulating/Detection of a major Lynch Syndrome-causing MLH1 founder variant in a large-scale genotyped cohorthttps://www.seppalalab.org/publication/sipila-2024-detection/Mon, 01 Jan 2024 00:00:00 +0000https://www.seppalalab.org/publication/sipila-2024-detection/Establishing Criteria for Tumor Necrosis as Prognostic Indicator in Colorectal Cancerhttps://www.seppalalab.org/publication/kastinen-2024-establishing/Mon, 01 Jan 2024 00:00:00 +0000https://www.seppalalab.org/publication/kastinen-2024-establishing/High immune cell infiltration predicts improved survival in cholangiocarcinomahttps://www.seppalalab.org/publication/wirta-2024-high/Mon, 01 Jan 2024 00:00:00 +0000https://www.seppalalab.org/publication/wirta-2024-high/Multiplexed analysis of macrophage polarisation in pulmonary metastases of microsatellite stable colorectal cancerhttps://www.seppalalab.org/publication/karjula-2024-multiplexed/Mon, 01 Jan 2024 00:00:00 +0000https://www.seppalalab.org/publication/karjula-2024-multiplexed/Quantitative Multiplexed Analysis of Indoleamine 2,3-Dioxygenase (IDO) and Arginase-1 (ARG1) Expression and Myeloid Cell Infiltration in Colorectal Cancerhttps://www.seppalalab.org/publication/elomaa-2024-quantitative/Mon, 01 Jan 2024 00:00:00 +0000https://www.seppalalab.org/publication/elomaa-2024-quantitative/The impact of preoperative treatments on the immune environment of rectal cancerhttps://www.seppalalab.org/publication/wirta-2024-the/Mon, 01 Jan 2024 00:00:00 +0000https://www.seppalalab.org/publication/wirta-2024-the/Clinical characteristics of pancreatic and biliary tract cancers in Lynch syndrome: A retrospective analysis from the Finnish National Lynch Syndrome Research Registryhttps://www.seppalalab.org/publication/zalevskaja-2023-clinical/Sun, 01 Jan 2023 00:00:00 +0000https://www.seppalalab.org/publication/zalevskaja-2023-clinical/Dominantly inherited micro-satellite instable cancer - the four Lynch syndromes - an EHTG, PLSD position statementhttps://www.seppalalab.org/publication/moller-2023-dominantly/Sun, 01 Jan 2023 00:00:00 +0000https://www.seppalalab.org/publication/moller-2023-dominantly/Immunological and prognostic significance of tumour necrosis in colorectal cancerhttps://www.seppalalab.org/publication/kastinen-2023-immunological/Sun, 01 Jan 2023 00:00:00 +0000https://www.seppalalab.org/publication/kastinen-2023-immunological/Lynch Syndrome Genetics and Clinical Implicationshttps://www.seppalalab.org/publication/peltomaki-2023-lynch/Sun, 01 Jan 2023 00:00:00 +0000https://www.seppalalab.org/publication/peltomaki-2023-lynch/Mortality by age, gene and gender in carriers of pathogenic mismatch repair gene variants receiving surveillance for early cancer diagnosis and treatment: a report from the prospective Lynch syndrome databasehttps://www.seppalalab.org/publication/dominguez-valentin-2023-mortality/Sun, 01 Jan 2023 00:00:00 +0000https://www.seppalalab.org/publication/dominguez-valentin-2023-mortality/Spatially resolved multimarker evaluation of CD274 (PD-L1)/PDCD1 (PD-1) immune checkpoint expression and macrophage polarisation in colorectal cancerhttps://www.seppalalab.org/publication/elomaa-2023-spatially/Sun, 01 Jan 2023 00:00:00 +0000https://www.seppalalab.org/publication/elomaa-2023-spatially/Systemic circulating microRNA landscape in Lynch syndromehttps://www.seppalalab.org/publication/sievanen-2023-systemic/Sun, 01 Jan 2023 00:00:00 +0000https://www.seppalalab.org/publication/sievanen-2023-systemic/Tertiary lymphoid structures in pulmonary metastases of microsatellite stable colorectal cancerhttps://www.seppalalab.org/publication/karjula-2023-tertiary/Sun, 01 Jan 2023 00:00:00 +0000https://www.seppalalab.org/publication/karjula-2023-tertiary/The prognostic role of tumor budding and tumor-stroma ratio in pulmonary metastasis of colorectal carcinomahttps://www.seppalalab.org/publication/karjula-2023-the/Sun, 01 Jan 2023 00:00:00 +0000https://www.seppalalab.org/publication/karjula-2023-the/Tumor-independent Detection of Inherited Mismatch Repair Deficiency for the Diagnosis of Lynch Syndrome with High Specificity and Sensitivityhttps://www.seppalalab.org/publication/kansikas-2023-tumor-independent/Sun, 01 Jan 2023 00:00:00 +0000https://www.seppalalab.org/publication/kansikas-2023-tumor-independent/Cancer Prevention with Resistant Starch in Lynch Syndrome Patients in the CAPP2-Randomized Placebo Controlled Trial: Planned 10-Year Follow-uphttps://www.seppalalab.org/publication/mathers-2022-cancer/Sat, 01 Jan 2022 00:00:00 +0000https://www.seppalalab.org/publication/mathers-2022-cancer/CD3(+) and CD8(+) T-Cell-Based Immune Cell Score and PD-(L)1 Expression in Pulmonary Metastases of Microsatellite Stable Colorectal Cancerhttps://www.seppalalab.org/publication/karjula-2022-cd3/Sat, 01 Jan 2022 00:00:00 +0000https://www.seppalalab.org/publication/karjula-2022-cd3/Prognostic significance of spatial and density analysis of T lymphocytes in colorectal cancerhttps://www.seppalalab.org/publication/elomaa-2022-prognostic/Sat, 01 Jan 2022 00:00:00 +0000https://www.seppalalab.org/publication/elomaa-2022-prognostic/The Different Immune Profiles of Normal Colonic Mucosa in Cancer-Free Lynch Syndrome Carriers and Lynch Syndrome Colorectal Cancer Patientshttps://www.seppalalab.org/publication/bohaumilitzky-2022-the/Sat, 01 Jan 2022 00:00:00 +0000https://www.seppalalab.org/publication/bohaumilitzky-2022-the/Body Weight, Physical Activity, and Risk of Cancer in Lynch Syndromehttps://www.seppalalab.org/publication/sievanen-2021-body/Fri, 01 Jan 2021 00:00:00 +0000https://www.seppalalab.org/publication/sievanen-2021-body/Distinct Mutational Profile of Lynch Syndrome Colorectal Cancers Diagnosed under Regular Colonoscopy Surveillancehttps://www.seppalalab.org/publication/ahadova-2021-distinct/Fri, 01 Jan 2021 00:00:00 +0000https://www.seppalalab.org/publication/ahadova-2021-distinct/Genetic and Epigenetic Characteristics of Inflammatory Bowel Disease-Associated Colorectal Cancerhttps://www.seppalalab.org/publication/rajamaki-2021-genetic/Fri, 01 Jan 2021 00:00:00 +0000https://www.seppalalab.org/publication/rajamaki-2021-genetic/Immune Contexture of MMR-Proficient Primary Colorectal Cancer and Matched Liver and Lung Metastaseshttps://www.seppalalab.org/publication/ahtiainen-2021-immune/Fri, 01 Jan 2021 00:00:00 +0000https://www.seppalalab.org/publication/ahtiainen-2021-immune/Immunoprofiles and DNA Methylation of Inflammatory Marker Genes in Ulcerative Colitis-Associated Colorectal Tumorigenesishttps://www.seppalalab.org/publication/maki-nevala-2021-immunoprofiles/Fri, 01 Jan 2021 00:00:00 +0000https://www.seppalalab.org/publication/maki-nevala-2021-immunoprofiles/Impact of Age and Comorbidity on Multimodal Management and Survival from Colorectal Cancer: A Population-Based Studyhttps://www.seppalalab.org/publication/kellokumpu-2021-impact/Fri, 01 Jan 2021 00:00:00 +0000https://www.seppalalab.org/publication/kellokumpu-2021-impact/No Difference in Penetrance between Truncating and Missense/Aberrant Splicing Pathogenic Variants in MLH1 and MSH2: A Prospective Lynch Syndrome Database Studyhttps://www.seppalalab.org/publication/dominguez-valentin-2021-no/Fri, 01 Jan 2021 00:00:00 +0000https://www.seppalalab.org/publication/dominguez-valentin-2021-no/Risk-reducing hysterectomy and bilateral salpingo-oophorectomy in female heterozygotes of pathogenic mismatch repair variants: a Prospective Lynch Syndrome Database reporthttps://www.seppalalab.org/publication/dominguez-valentin-2021-risk-reducing/Fri, 01 Jan 2021 00:00:00 +0000https://www.seppalalab.org/publication/dominguez-valentin-2021-risk-reducing/The "unnatural" history of colorectal cancer in Lynch syndrome: Lessons from colonoscopy surveillancehttps://www.seppalalab.org/publication/ahadova-2021-the/Fri, 01 Jan 2021 00:00:00 +0000https://www.seppalalab.org/publication/ahadova-2021-the/Uptake of hysterectomy and bilateral salpingo-oophorectomy in carriers of pathogenic mismatch repair variants: a Prospective Lynch Syndrome Database reporthttps://www.seppalalab.org/publication/seppala-2021-uptake/Fri, 01 Jan 2021 00:00:00 +0000https://www.seppalalab.org/publication/seppala-2021-uptake/Associations of Pathogenic Variants in MLH1, MSH2, and MSH6 With Risk of Colorectal Adenomas and Tumors and With Somatic Mutations in Patients With Lynch Syndromehttps://www.seppalalab.org/publication/engel-2020-associations/Wed, 01 Jan 2020 00:00:00 +0000https://www.seppalalab.org/publication/engel-2020-associations/Cancer risks by gene, age, and gender in 6350 carriers of pathogenic mismatch repair variants: findings from the Prospective Lynch Syndrome Databasehttps://www.seppalalab.org/publication/dominguez-valentin-2020-cancer/Wed, 01 Jan 2020 00:00:00 +0000https://www.seppalalab.org/publication/dominguez-valentin-2020-cancer/Correction: Cancer risks by gene, age, and gender in 6350 carriers of pathogenic mismatch repair variants: findings from the Prospective Lynch Syndrome Databasehttps://www.seppalalab.org/publication/dominguez-valentin-2020-correction/Wed, 01 Jan 2020 00:00:00 +0000https://www.seppalalab.org/publication/dominguez-valentin-2020-correction/Factors associated with decision-making on prophylactic hysterectomy and attitudes towards gynecological surveillance among women with Lynch syndrome (LS): a descriptive studyhttps://www.seppalalab.org/publication/kalamo-2020-factors/Wed, 01 Jan 2020 00:00:00 +0000https://www.seppalalab.org/publication/kalamo-2020-factors/Prognostic Value of Immune Environment Analysis in Small Bowel Adenocarcinomas with Verified Mutational Landscape and Predisposing Conditionshttps://www.seppalalab.org/publication/wirta-2020-prognostic/Wed, 01 Jan 2020 00:00:00 +0000https://www.seppalalab.org/publication/wirta-2020-prognostic/Risk-Reducing Gynecological Surgery in Lynch Syndrome: Results of an International Survey from the Prospective Lynch Syndrome Databasehttps://www.seppalalab.org/publication/dominguez-valentin-2020-risk-reducing/Wed, 01 Jan 2020 00:00:00 +0000https://www.seppalalab.org/publication/dominguez-valentin-2020-risk-reducing/Epidemiological, clinical and molecular characterization of Lynch-like syndrome: A population-based studyhttps://www.seppalalab.org/publication/porkka-2019-epidemiological/Tue, 01 Jan 2019 00:00:00 +0000https://www.seppalalab.org/publication/porkka-2019-epidemiological/Exome and immune cell score analyses reveal great variation within synchronous primary colorectal cancershttps://www.seppalalab.org/publication/hanninen-2019-exome/Tue, 01 Jan 2019 00:00:00 +0000https://www.seppalalab.org/publication/hanninen-2019-exome/Lack of association between screening interval and cancer stage in Lynch syndrome may be accounted for by over-diagnosis; a prospective Lynch syndrome database reporthttps://www.seppalalab.org/publication/seppala-2019-lack/Tue, 01 Jan 2019 00:00:00 +0000https://www.seppalalab.org/publication/seppala-2019-lack/Survival by colon cancer stage and screening interval in Lynch syndrome: a prospective Lynch syndrome database reporthttps://www.seppalalab.org/publication/dominguez-valentin-2019-survival/Tue, 01 Jan 2019 00:00:00 +0000https://www.seppalalab.org/publication/dominguez-valentin-2019-survival/Cancer risk and survival in path_MMR carriers by gene and gender up to 75 years of age: a report from the Prospective Lynch Syndrome Databasehttps://www.seppalalab.org/publication/moller-2018-cancer/Mon, 01 Jan 2018 00:00:00 +0000https://www.seppalalab.org/publication/moller-2018-cancer/Subtotal Colectomy for Colon Cancer Reduces the Need for Subsequent Surgery in Lynch Syndromehttps://www.seppalalab.org/publication/renkonen-sinisalo-2017-subtotal/Sun, 01 Jan 2017 00:00:00 +0000https://www.seppalalab.org/publication/renkonen-sinisalo-2017-subtotal/Uptake of genetic testing by the children of Lynch syndrome variant carriers across three generationshttps://www.seppalalab.org/publication/seppala-2017-uptake/Sun, 01 Jan 2017 00:00:00 +0000https://www.seppalalab.org/publication/seppala-2017-uptake/Combination of microsatellite instability and BRAF mutation status for subtyping colorectal cancerhttps://www.seppalalab.org/publication/seppala-2015-combination/Thu, 01 Jan 2015 00:00:00 +0000https://www.seppalalab.org/publication/seppala-2015-combination/