Seppala TT
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- Distance-based evaluation of tumor budding in colorectal cancer
- Impact of stromal maturity and proportion on prognosis and immune landscape in colorectal cancer
- Integrative omics approaches to uncover liquid-based cancer-predicting biomarkers in Lynch syndrome
- Leveraging glucan-induced trained immunity for the epigenetic and metabolic rewiring of macrophages to enhance colorectal cancer vaccine response
- MLH1 Lynch Syndrome Colorectal Cancers Are Driven by Heterogeneous Wnt Pathway Gene Mutations
- Nanopore sequencing reveals hidden landscape of short L1 transductions in colorectal cancer
- NOUS-209 Off-the-shelf Immunotherapy Has the Potential to Hit Primary and Metachronous Colorectal and Urothelial Cancers in Lynch Syndrome
- Quantitative analysis of myeloid cell patterns and immunosuppressive enzyme (IDO, ARG1) expression in colorectal cancer pulmonary metastases and corresponding primary tumours
- Sex-based differences in circulating microRNA and metabolite signatures associated with physical activity in Lynch Syndrome carriers
- Significance of tumor infiltrating granulocytes and neutrophil extracellular traps in colorectal cancer
- Tumour immune contexture and immune evasion in sporadic and Lynch syndrome-associated microsatellite unstable colorectal cancers
- Unraveling the Effects and Characteristics of Proliferating Tumor and Cytotoxic T Cells in Colorectal Cancer
- Urothelium marker UPK2 identifies aggressive colorectal cancers with distinct molecular and histological features
- Associations of mucinous differentiation and mucin expression with immune cell infiltration and prognosis in colorectal adenocarcinoma
- CDX2 and SATB2 loss are associated with myeloid cell infiltration and poor survival in colorectal cancer
- Characteristics and significance of gammadelta T cells in colorectal cancer
- Colorectal cancer heterogeneity co-evolves with tumor architecture to determine disease outcome
- Colorectal carcinogenesis in the Lynch syndromes and familial adenomatous polyposis: trigger events and downstream consequences
- Commentary on Estimating cancer risk in carriers of Lynch syndrome variants in UK Biobank
- Comprehensive characterization of micropapillary colorectal adenocarcinoma
- Comprehensive metabolomic and epigenomic characterization of microsatellite stable BRAF-mutated colorectal cancer
- Constrained hypermutation and absence of TERT promoter mutations in Lynch syndrome-associated urothelial cancer
- Genome-wide DNA methylation profiles of colorectal tumors in Lynch syndrome and familial adenomatous polyposis
- Integrating Tumor Intraepithelial CD8(+) and Stromal FOXP3(+) T-Cell Densities as an Enhanced Immune Prognostic Index in Colorectal Cancer
- Multimarker Assessment of B-Cell and Plasma Cell Subsets and Their Prognostic Role in the Colorectal Cancer Microenvironment
- Performance Comparison of Droplet Digital PCR and Next-Generation Sequencing for Circulating Tumor DNA Detection in Non-Metastatic Rectal Cancer
- Prognostic Features and Potential for Immune Therapy in Metastatic Mismatch Repair-Deficient Colorectal Cancer: A Retrospective Analysis of a Large Consecutive Population-Based Patient Series
- PTEN status, tumor immune microenvironment, and survival in colorectal cancer
- Significance of mucin-suspended tumor bud-like structures in colorectal cancer
- Significance of Th1 and Th2 Cell Densities and Th1/Th2 Cytokine Profiles in Colorectal Cancer
- Skin cancer risk in hereditary mixed cancer syndromes
- Stroma AReactive Invasion Front Areas (SARIFA), tumour immune microenvironment, and survival in colorectal cancer
- Structural features of somatic and germline retrotransposition events in humans
- Therapeutic Targeting of Oncogene-Induced Transcription-Replication Conflicts in Pancreatic Ductal Adenocarcinoma
- Circulating metabolome landscape in Lynch syndrome
- Circulating miRNA Signature Predicts Cancer Incidence in Lynch Syndrome-A Pilot Study
- Detection of a major Lynch Syndrome-causing MLH1 founder variant in a large-scale genotyped cohort
- Establishing Criteria for Tumor Necrosis as Prognostic Indicator in Colorectal Cancer
- Genome-wide polygenic risk scores for colorectal cancer have implications for risk-based screening
- High immune cell infiltration predicts improved survival in cholangiocarcinoma
- In vivo CRISPR screening identifies geranylgeranyl diphosphate as a pancreatic cancer tumor growth dependency
- Multiplexed analysis of macrophage polarisation in pulmonary metastases of microsatellite stable colorectal cancer
- Patient-derived Organoid Pharmacotyping As A Predictive Tool for Therapeutic Selection in Pancreatic Ductal Adenocarcinoma
- Quantitative Multiplexed Analysis of Indoleamine 2,3-Dioxygenase (IDO) and Arginase-1 (ARG1) Expression and Myeloid Cell Infiltration in Colorectal Cancer
- The impact of preoperative treatments on the immune environment of rectal cancer
- Transfer Learning Reveals Cancer-Associated Fibroblasts Are Associated with Epithelial-Mesenchymal Transition and Inflammation in Cancer Cells in Pancreatic Ductal Adenocarcinoma
- Updated European guidelines for clinical management of familial adenomatous polyposis (FAP), MUTYH-associated polyposis (MAP), gastric adenocarcinoma, proximal polyposis of the stomach (GAPPS) and other rare adenomatous polyposis syndromes: a joint EHTG-ESCP revision
- A simple approach for detecting HLA-A*02 alleles in archival formalin-fixed paraffin-embedded tissue samples and an application example for studying cancer immunoediting
- Clinical characteristics of pancreatic and biliary tract cancers in Lynch syndrome: A retrospective analysis from the Finnish National Lynch Syndrome Research Registry
- Delphi Initiative for Early-Onset Colorectal Cancer (DIRECt) International Management Guidelines
- Dominantly inherited micro-satellite instable cancer - the four Lynch syndromes - an EHTG, PLSD position statement
- Editorial: Identification, risk stratification, and optimized management for Lynch Syndrome
- Hereditary colorectal, gastric, and pancreatic cancer: comprehensive review
- Immunological and prognostic significance of tumour necrosis in colorectal cancer
- Lynch Syndrome Genetics and Clinical Implications
- Mortality by age, gene and gender in carriers of pathogenic mismatch repair gene variants receiving surveillance for early cancer diagnosis and treatment: a report from the prospective Lynch syndrome database
- Spatially resolved multimarker evaluation of CD274 (PD-L1)/PDCD1 (PD-1) immune checkpoint expression and macrophage polarisation in colorectal cancer
- Systemic circulating microRNA landscape in Lynch syndrome
- Tertiary lymphoid structures in pulmonary metastases of microsatellite stable colorectal cancer
- The prognostic role of tumor budding and tumor-stroma ratio in pulmonary metastasis of colorectal carcinoma
- Tumor-independent Detection of Inherited Mismatch Repair Deficiency for the Diagnosis of Lynch Syndrome with High Specificity and Sensitivity
- Cancer Prevention with Resistant Starch in Lynch Syndrome Patients in the CAPP2-Randomized Placebo Controlled Trial: Planned 10-Year Follow-up
- CD3(+) and CD8(+) T-Cell-Based Immune Cell Score and PD-(L)1 Expression in Pulmonary Metastases of Microsatellite Stable Colorectal Cancer
- Precision Medicine in Pancreatic Cancer: Patient-Derived Organoid Pharmacotyping Is a Predictive Biomarker of Clinical Treatment Response
- Prognostic significance of spatial and density analysis of T lymphocytes in colorectal cancer
- Response to Chambuso et al
- Solving for Chemotherapeutic Sensitivity: Adapting "Black Box" Methods to Study Patient-Derived Tumor Organoids
- The Different Immune Profiles of Normal Colonic Mucosa in Cancer-Free Lynch Syndrome Carriers and Lynch Syndrome Colorectal Cancer Patients
- The prognostic value of extramural venous invasion in preoperative MRI of rectal cancer patients
- Analysis in the Prospective Lynch Syndrome Database identifies sarcoma as part of the Lynch syndrome tumor spectrum
- Body Weight, Physical Activity, and Risk of Cancer in Lynch Syndrome
- Can Pancreatic Organoids Help in the Treatment of Pancreatic Cancer?
- Distinct Mutational Profile of Lynch Syndrome Colorectal Cancers Diagnosed under Regular Colonoscopy Surveillance
- European guidelines from the EHTG and ESCP for Lynch syndrome: an updated third edition of the Mallorca guidelines based on gene and gender
- Genetic and Epigenetic Characteristics of Inflammatory Bowel Disease-Associated Colorectal Cancer
- Immune Contexture of MMR-Proficient Primary Colorectal Cancer and Matched Liver and Lung Metastases
- Immunoprofiles and DNA Methylation of Inflammatory Marker Genes in Ulcerative Colitis-Associated Colorectal Tumorigenesis
- Impact of Age and Comorbidity on Multimodal Management and Survival from Colorectal Cancer: A Population-Based Study
- No Difference in Penetrance between Truncating and Missense/Aberrant Splicing Pathogenic Variants in MLH1 and MSH2: A Prospective Lynch Syndrome Database Study
- Prospective observational data informs understanding and future management of Lynch syndrome: insights from the Prospective Lynch Syndrome Database (PLSD)
- Risk-reducing hysterectomy and bilateral salpingo-oophorectomy in female heterozygotes of pathogenic mismatch repair variants: a Prospective Lynch Syndrome Database report
- The "unnatural" history of colorectal cancer in Lynch syndrome: Lessons from colonoscopy surveillance
- Towards evidence-based personalised precision medicine for Lynch syndrome
- Uptake of hysterectomy and bilateral salpingo-oophorectomy in carriers of pathogenic mismatch repair variants: a Prospective Lynch Syndrome Database report
- Associations of Pathogenic Variants in MLH1, MSH2, and MSH6 With Risk of Colorectal Adenomas and Tumors and With Somatic Mutations in Patients With Lynch Syndrome
- Cancer risks by gene, age, and gender in 6350 carriers of pathogenic mismatch repair variants: findings from the Prospective Lynch Syndrome Database
- Correction: Cancer risks by gene, age, and gender in 6350 carriers of pathogenic mismatch repair variants: findings from the Prospective Lynch Syndrome Database
- Factors associated with decision-making on prophylactic hysterectomy and attitudes towards gynecological surveillance among women with Lynch syndrome (LS): a descriptive study
- Patient-derived Organoid Pharmacotyping is a Clinically Tractable Strategy for Precision Medicine in Pancreatic Cancer
- Prognostic Value of Immune Environment Analysis in Small Bowel Adenocarcinomas with Verified Mutational Landscape and Predisposing Conditions
- Response to Tolva et al
- Risk-Reducing Gynecological Surgery in Lynch Syndrome: Results of an International Survey from the Prospective Lynch Syndrome Database
- Epidemiological, clinical and molecular characterization of Lynch-like syndrome: A population-based study
- Exome and immune cell score analyses reveal great variation within synchronous primary colorectal cancers
- Lack of association between screening interval and cancer stage in Lynch syndrome may be accounted for by over-diagnosis; a prospective Lynch syndrome database report
- Survival by colon cancer stage and screening interval in Lynch syndrome: a prospective Lynch syndrome database report
- Cancer risk and survival in path_MMR carriers by gene and gender up to 75 years of age: a report from the Prospective Lynch Syndrome Database
- Correction: Mortality and Length of Stay of Very Low Birth Weight and Very Preterm Infants: A EuroHOPE Study
- Subtotal Colectomy for Colon Cancer Reduces the Need for Subsequent Surgery in Lynch Syndrome
- Uptake of genetic testing by the children of Lynch syndrome variant carriers across three generations
- Amyloid-beta and Tau Dynamics in Human Brain Interstitial Fluid in Patients with Suspected Normal Pressure Hydrocephalus
- Coexisting ipsilateral right femoral hernia and incarcerated obturator hernia
- Combination of microsatellite instability and BRAF mutation status for subtyping colorectal cancer
- De Garengeot's hernia: 40 years after Bassini inguinal hernioplasty
- Individual and Regional-level Factors Contributing to Variation in Length of Stay After Cerebral Infarction in Six European Countries
- Mortality and Length of Stay of Very Low Birth Weight and Very Preterm Infants: A EuroHOPE Study
- Outcome, Use of Resources and Their Relationship in the Treatment of AMI, Stroke and Hip Fracture at European Hospitals
- Towards Explaining International Differences in Health Care Performance: Results of the EuroHOPE Project
- Treatment provided in the Public Dental Service in Finland in 2009
- Cerebrospinal fluid biomarker and brain biopsy findings in idiopathic normal pressure hydrocephalus
- Comparison between clinical diagnosis and CSF biomarkers of Alzheimer disease in elderly patients with late onset psychosis: Helsinki Old Age Psychosis Study (HOPS)
- Health care performance comparison using a disease-based approach: the EuroHOPE project
- CSF biomarkers for Alzheimer disease correlate with cortical brain biopsy findings
- A methodological approach for register-based evaluation of cost and outcomes in health care
- Longitudinal changes of CSF biomarkers in Alzheimer's disease
- Plasma Abeta42 and Abeta40 as markers of cognitive change in follow-up: a prospective, longitudinal, population-based cohort study
- National learning curve for laparoscopic hysterectomy and trends in hysterectomy in Finland 2000-2005