Seppälä Lab

Funding & Collaboration

Sun, 03 May 2026 00:00:00 +0000

Colorectal Cancer Awareness Month: Burak Yavuz speaks with Toni Seppälä

Fri, 27 Mar 2026 00:00:00 +0000

During Colorectal Cancer Awareness Month, Burak Yavuz sat down with Toni Seppälä for an 8-minute discussion hosted by the European Society of Coloproctology (ESCP), focused on one of the most pressing challenges in colorectal cancer today: the rising incidence of early-onset colorectal cancer (EOCRC).

Burak asks Toni about the key drivers behind the increasing global incidence, how to distinguish hereditary syndromes from apparently sporadic cases, whether current genetic assessment strategies are keeping pace, and which red flags in younger patients should prompt earlier investigation in daily practice.

Distance-based evaluation of tumor budding in colorectal cancer

Thu, 01 Jan 2026 00:00:00 +0000

Impact of stromal maturity and proportion on prognosis and immune landscape in colorectal cancer

Thu, 01 Jan 2026 00:00:00 +0000

Integrative omics approaches to uncover liquid-based cancer-predicting biomarkers in Lynch syndrome

Thu, 01 Jan 2026 00:00:00 +0000

Leveraging glucan-induced trained immunity for the epigenetic and metabolic rewiring of macrophages to enhance colorectal cancer vaccine response

Thu, 01 Jan 2026 00:00:00 +0000

MLH1 Lynch Syndrome Colorectal Cancers Are Driven by Heterogeneous Wnt Pathway Gene Mutations

Thu, 01 Jan 2026 00:00:00 +0000

Nanopore sequencing reveals hidden landscape of short L1 transductions in colorectal cancer

Thu, 01 Jan 2026 00:00:00 +0000

NOUS-209 Off-the-shelf Immunotherapy Has the Potential to Hit Primary and Metachronous Colorectal and Urothelial Cancers in Lynch Syndrome

Thu, 01 Jan 2026 00:00:00 +0000

Quantitative analysis of myeloid cell patterns and immunosuppressive enzyme (IDO, ARG1) expression in colorectal cancer pulmonary metastases and corresponding primary tumours

Thu, 01 Jan 2026 00:00:00 +0000

Sex-based differences in circulating microRNA and metabolite signatures associated with physical activity in Lynch Syndrome carriers

Thu, 01 Jan 2026 00:00:00 +0000

Significance of tumor infiltrating granulocytes and neutrophil extracellular traps in colorectal cancer

Thu, 01 Jan 2026 00:00:00 +0000

The PREDI-LYNCH project

Thu, 01 Jan 2026 00:00:00 +0000

The PREDI-LYNCH project is dedicated to advancing early detection and personalized prevention of Lynch syndrome, a hereditary condition that predisposes individuals to colorectal, endometrial, and several other types of cancer.

Through collaboration with leading medical institutions and researchers, the project aims to refine risk assessment tools that combine genetic markers, family history, and lifestyle factors. This holistic approach enables healthcare providers to offer tailored screening and prevention strategies, ultimately reducing cancer incidence and improving long-term patient outcomes.

PREDI-LYNCH also emphasizes patient education and accessibility, ensuring that risk prediction tools are user-friendly and available to diverse populations. By bridging the gap between research and clinical practice, the PREDI-LYNCH project strives to empower individuals and clinicians alike with actionable insights for precision medicine in hereditary cancer prevention.

Duration: 2025–2031
Role: Leader of clinical studies

Tumour immune contexture and immune evasion in sporadic and Lynch syndrome-associated microsatellite unstable colorectal cancers

Thu, 01 Jan 2026 00:00:00 +0000

Unraveling the Effects and Characteristics of Proliferating Tumor and Cytotoxic T Cells in Colorectal Cancer

Thu, 01 Jan 2026 00:00:00 +0000

Urothelium marker UPK2 identifies aggressive colorectal cancers with distinct molecular and histological features

Thu, 01 Jan 2026 00:00:00 +0000

EUR 13.6 Million Funding for Early Detection of Lynch Syndrome Cancers

Thu, 15 May 2025 00:00:00 +0000

Seppälä Lab has received EUR 13.6 million in funding to advance early detection of Lynch syndrome-associated cancers. Lynch syndrome is one of the most common hereditary cancer predisposition syndromes, significantly increasing lifetime risk of colorectal, endometrial, and other cancers.

This funding will support development of novel screening approaches and biomarkers aimed at earlier, more accurate detection — improving outcomes for Lynch syndrome carriers and their families.

Read the full news article at Tampere University →

Advancing Cancer Research Through Foundation and Donor Funding

Tue, 06 May 2025 00:00:00 +0000

Cancer Foundation Finland (Syöpäsäätiö) has awarded Toni Seppälä a EUR 150,000 grant to support a two-year patient study aimed at optimizing colorectal cancer treatment using modern methods.

The study will use tumor DNA analysis from blood samples to identify effective and safe treatment combinations for individual patients, with a focus on colorectal cancer subtypes that respond to immunotherapy.

Read the full article at Syöpäsäätiö →

Associations of mucinous differentiation and mucin expression with immune cell infiltration and prognosis in colorectal adenocarcinoma