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Distance-based evaluation of tumor budding in colorectal cancer
Colorectal cancer cells sometimes break away from the main tumor and spread outward as tiny clusters — a phenomenon pathologists call …
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Distance-based evaluation of tumor budding in colorectal cancer
Epithelial interferon-stimulated gene programs modulate chemotherapy sensitivity in colorectal cancer via EPSTI1
We used patient-derived tumor organoids to study the molecular factors underlying heterogeneous chemotherapy responses in colorectal …
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ESGO Consensus Statement on endometrial cancer prevention, risk reduction strategies, and management of women with Lynch syndrome
Lynch syndrome (LS) is a hereditary condition associated with an increased susceptibility to developing cancer, primarily colorectal …
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Impact of stromal maturity and proportion on prognosis and immune landscape in colorectal cancer
The tissue surrounding a tumor — called stroma — is not passive filler; its composition and abundance can shape how aggressively a …
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Impact of stromal maturity and proportion on prognosis and immune landscape in colorectal cancer
Incidence Rates of Melanoma and Lung Cancer Are Generally Low in the Lynch Syndromes and Vary Across path_MMR Variants: A Prospective Lynch Syndrome Database Report
Background/Objectives: It is not established whether melanoma and lung cancer are part of the tumor spectrum of the Lynch syndromes …
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Integrative omics approaches to uncover liquid-based cancer-predicting biomarkers in Lynch syndrome
Lynch syndrome is a genetic cancer-predisposing syndrome caused by pathogenic mutations in DNA mismatch repair (path_MMR) genes. Due to …
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Leveraging glucan-induced trained immunity for the epigenetic and metabolic rewiring of macrophages to enhance colorectal cancer vaccine response
Colorectal cancer (CRC) remains refractory to most immunotherapies, with cancer vaccines failing due to an immunosuppressive tumor …
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MLH1 Lynch Syndrome Colorectal Cancers Are Driven by Heterogeneous Wnt Pathway Gene Mutations
Lynch syndrome–associated colorectal cancers in MLH1 mutation carriers are driven by somatic mutations in Wnt signaling pathway genes. …
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MLH1 Lynch Syndrome Colorectal Cancers Are Driven by Heterogeneous Wnt Pathway Gene Mutations
Nanopore sequencing reveals hidden landscape of short L1 transductions in colorectal cancer
L1s are repetitive sequences capable of copying themselves into new genomic loci. While L1s are typically repressed by DNA methylation …
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NOUS-209 Off-the-shelf Immunotherapy Has the Potential to Hit Primary and Metachronous Colorectal and Urothelial Cancers in Lynch Syndrome
People with Lynch syndrome inherit a high risk of several cancers, and their tumours carry distinctive protein fragments produced by a …
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