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Distance-based evaluation of tumor budding in colorectal cancer
Colorectal cancer cells sometimes break away from the main tumor and spread outward as tiny clusters — a phenomenon pathologists call …
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Distance-based evaluation of tumor budding in colorectal cancer
Impact of stromal maturity and proportion on prognosis and immune landscape in colorectal cancer
The tissue surrounding a tumor — called stroma — is not passive filler; its composition and abundance can shape how aggressively a …
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Impact of stromal maturity and proportion on prognosis and immune landscape in colorectal cancer
Integrative omics approaches to uncover liquid-based cancer-predicting biomarkers in Lynch syndrome
Lynch syndrome is a genetic cancer-predisposing syndrome caused by pathogenic mutations in DNA mismatch repair (path_MMR) genes. Due to …
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Leveraging glucan-induced trained immunity for the epigenetic and metabolic rewiring of macrophages to enhance colorectal cancer vaccine response
Colorectal cancer (CRC) remains refractory to most immunotherapies, with cancer vaccines failing due to an immunosuppressive tumor …
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MLH1 Lynch Syndrome Colorectal Cancers Are Driven by Heterogeneous Wnt Pathway Gene Mutations
Lynch syndrome–associated colorectal cancers in MLH1 mutation carriers are driven by somatic mutations in Wnt signaling pathway genes. …
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MLH1 Lynch Syndrome Colorectal Cancers Are Driven by Heterogeneous Wnt Pathway Gene Mutations
Nanopore sequencing reveals hidden landscape of short L1 transductions in colorectal cancer
L1s are repetitive sequences capable of copying themselves into new genomic loci. While L1s are typically repressed by DNA methylation …
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NOUS-209 Off-the-shelf Immunotherapy Has the Potential to Hit Primary and Metachronous Colorectal and Urothelial Cancers in Lynch Syndrome
Lynch syndrome is characterized by the development of microsatellite-instable cancers that share neoantigens, offering an opportunity …
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Quantitative analysis of myeloid cell patterns and immunosuppressive enzyme (IDO, ARG1) expression in colorectal cancer pulmonary metastases and corresponding primary tumours
Indoleamine-2,3-dioxygenase (IDO) and arginase1 (ARG1) are immunosuppressive enzymes frequently overexpressed in cancer, with higher …
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Sex-based differences in circulating microRNA and metabolite signatures associated with physical activity in Lynch Syndrome carriers
Lynch syndrome carriers face a high cancer risk, especially colorectal cancer. Although physical activity is known to reduce cancer …
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Significance of tumor infiltrating granulocytes and neutrophil extracellular traps in colorectal cancer
BACKGROUND: Neutrophils are the most abundant granulocytes in the tumor microenvironment and exert both pro- and anti-cancer effects. …
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