Lynch Syndrome | Seppälä Lab

Colorectal Cancer Awareness Month: Burak Yavuz speaks with Toni Seppälä

Fri, 27 Mar 2026 00:00:00 +0000

During Colorectal Cancer Awareness Month, Burak Yavuz sat down with Toni Seppälä for an 8-minute discussion hosted by the European Society of Coloproctology (ESCP), focused on one of the most pressing challenges in colorectal cancer today: the rising incidence of early-onset colorectal cancer (EOCRC).

Burak asks Toni about the key drivers behind the increasing global incidence, how to distinguish hereditary syndromes from apparently sporadic cases, whether current genetic assessment strategies are keeping pace, and which red flags in younger patients should prompt earlier investigation in daily practice.

The PREDI-LYNCH project

Thu, 01 Jan 2026 00:00:00 +0000

The PREDI-LYNCH project is dedicated to advancing early detection and personalized prevention of Lynch syndrome, a hereditary condition that predisposes individuals to colorectal, endometrial, and several other types of cancer.

Through collaboration with leading medical institutions and researchers, the project aims to refine risk assessment tools that combine genetic markers, family history, and lifestyle factors. This holistic approach enables healthcare providers to offer tailored screening and prevention strategies, ultimately reducing cancer incidence and improving long-term patient outcomes.

PREDI-LYNCH also emphasizes patient education and accessibility, ensuring that risk prediction tools are user-friendly and available to diverse populations. By bridging the gap between research and clinical practice, the PREDI-LYNCH project strives to empower individuals and clinicians alike with actionable insights for precision medicine in hereditary cancer prevention.

Duration: 2025–2031
Role: Leader of clinical studies

EUR 13.6 Million Funding for Early Detection of Lynch Syndrome Cancers

Thu, 15 May 2025 00:00:00 +0000

Seppälä Lab has received EUR 13.6 million in funding to advance early detection of Lynch syndrome-associated cancers. Lynch syndrome is one of the most common hereditary cancer predisposition syndromes, significantly increasing lifetime risk of colorectal, endometrial, and other cancers.

This funding will support development of novel screening approaches and biomarkers aimed at earlier, more accurate detection — improving outcomes for Lynch syndrome carriers and their families.

Read the full news article at Tampere University →